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This story about assassins takes place in a fanciful world. Yim Mo (Wayne Lai), who used to have a prestigious nickname “Yama”, has caused his family to break up with fatal consequences due to his blunder. He ends up as a mediocre killer. He has facilitated the emergence of a formidable hitman called Kiu Sing (Moses Chan), aka “Zero”. However, the duo’s destinies are rewritten because of a Taiwanese tycoon called Or Ching-hung. Yim Mo counts himself lucky as his buddy Yiu Suk-han (Elena Kong), who is a hooker by profession, manages to bridge the communication gap between him and his daughter Yim So-chi (Louisa Mak). Unfortunately, Yim Mo’s life has become very difficult as an eccentric female assassin called Yik Lan (Katy Kung) keeps clinging to him. Kiu Sing opens a cafe as a decoy and hires a single mother called Chin Heung-sin (Ali Lee). He also has a crush on Lam Sum-sum (Samantha Ko), who is a temple keeper with a mysterious background. Yim Mo and Kiu Sing are forced to engage each other in a duel as Assassin Hunter shows up.

這是一個發生於抽離世界的殺手故事︰曾被尊稱「閻王」的閻武 (黎耀祥飾)，闖禍導致家散人亡，淪為低端殺手，造就神級殺手「Zero」喬星 (陳豪飾) 崛起，殊不知二人曾各自因台灣富商柯正雄而改寫了命運……閻武幸有知己鳳姐姚淑嫻 (江美儀飾)，成為他與女兒閰素之 (麥明詩飾) 的聯繫橋樑，卻不幸被行事乖張的女殺手易蘭 (龔嘉欣飾) 纏着，叫苦連天。喬星開設咖啡室作掩飾，聘請了單親媽媽錢向茜 (李佳芯飾)，並心儀身分撲朔迷離的廟祝林森森 (高海寧飾)。「殺手獵人」出現，迫使閻武與喬星來個生死對決……

Rewind seven years and two families are ruined due to a serious traffic accident, causing destinies of Keung Yuk-shing (Frankie Lam) and Fong Lok-man (Priscilla Wong) to be rewritten. Fast-forward seven years and because of a traffic accident, Yuk-shing runs into Lok-man again. Life is still filled with ups and downs. Lok-man and her younger sister Fong Shu-man (Shiga Lin) do not get along like they used to as people close to them are leaving one after another. An eccentric doctor by the name of Koo Hei-san (Mark Ma) unexpectedly manages to get to the bottom of the problem. Lok-man is busily looking after her daughter Chu Hang-yee and stepson Chu Ka-bing (Zeno Koo). Yuk-shing, on the other hand, never understands the needs of his only daughter Keung Tsz-yau (Chloe So). Fate brings Tsz-yau and Ka-bing together. Their mutual friend Mok Yu-him (Kyle Li) comes across even more problems because of their relationship, which also causes the truth about a traffic accident that took place all those years ago to gradually surface. The chums even have to prepare for change again.

七年前一宗嚴重車禍，破壞了兩個家庭，改變了姜煜誠(林文龍飾)、方樂汶(黃翠如飾)的人生。七年後一次交通意外，讓煜誠重遇樂汶，生活仍然有悲有喜。樂汶與妹妹方書文(連詩雅飾)因身邊人逐一離開而鬧僵，沒想到行為怪異的醫生古希晨(馬貫東飾)，卻能直搗問題根源。樂汶忙於照顧女兒朱幸而及繼子朱嘉炳(顧定軒飾)，煜誠則一直未能了解獨女姜子優(蘇皓兒飾)的需要。子優和嘉炳因緣走近，共同朋友莫宇謙(李任燊飾)竟為此段關係衍生更多問題，也令當年車禍真相漸漸浮現，眾人亦要再次面臨改變……